Diethyl Ether → [2-(5,5-Dimethyl-2-oxo-imidazolidin-1-yl)-ethyl]-carbamic acid tert-butyl ester

{2-[(Cyano-dimethyl-methyl)-amino]-ethyl}-carbamic acid tert-butyl ester (0.74 g., 3.3 mmol) was dissolved in THF (2 mL), cooled in an ice bath, and a 1.0 M solution of LiAlH4 in Et2O (6.5 mL, 6.5 mmol) was added dropwise. The resulting suspension was stirred in the ice bath for 3 h and then quenched (i. 0.17 mL of water; ii. 0.17 mL of 4 M aqueous NaOH; iii. 0.84 mL of water). The resulting mixture was diluted with THF (50 mL) and stirred for 15 min. The mixture was filtered and the filtrate concentrated to give an oil. The oil was dissolved in THF (10 mL), DIPEA (1.4 mL) was added, and the mixture was stirred in an ice bath. A solution of p-nitrophenyl chloroformate (800 mg, 4.0 mmol) in THF (8 mL) was added dropwise and the resulting yellow solution was stirred for 16 h. The mixture was concenatrated, dissolved in DCM (50 mL) and washed with 0.5 M HCl (50 mL) followed by saturated aqueous NaHCO3 solution (50 mL). The organic layer was dried (Na2SO4), concentrated and purified by flash chromatography (EtOAc) to give the product as a pale yellow gum (450 mg, 54%).

1. temperaturecooled in an ice bath
2. customquenched (i. 0.17 mL of water; ii. 0.17 mL of 4 M aqueous NaOH; iii. 0.84 mL of water)
3. additionThe resulting mixture was diluted with THF (50 mL)
4. filtrationThe mixture was filtered
5. concentrationthe filtrate concentrated
6. customto give an oil
7. stirringthe mixture was stirred in an ice bath
8. stirringthe resulting yellow solution was stirred for 16 h
9. washwashed with 0.5 M HCl (50 mL)
10. dry with materialThe organic layer was dried (Na2SO4)
11. concentrationconcentrated
12. custompurified by flash chromatography (EtOAc)

ORD record

ord-8c979b974e1a4f478e7d9f29950b618c

Source dataset

uspto-grants-2010_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07786132B2