反应详情

A mixture of 4-acetylbenzene-1-sulfonyl chloride (2 g, 9.2 mmol), piperidine (0.85 g, 10.0 mmol) and triethylamine (1.9 g, 18.4 mmol) in tetrahydrofuran (60 mL) was stirred at rt overnight. Brine (100 mL) was added and the mixture was extracted with ethyl acetate (3×100 mL). The combined organic layer was washed with brine (100 mL), dried over anhydrous sodium sulfate and filtered. Removal of solvent in vacuo gave the title compound as a white solid (2.3 g, 94%). MS (M+H)+ 268.

1. extractionthe mixture was extracted with ethyl acetate (3×100 mL)
2. washThe combined organic layer was washed with brine (100 mL)
3. dry with materialdried over anhydrous sodium sulfate
4. filtrationfiltered
5. customRemoval of solvent in vacuo