Sodium sulfate decahydrate → HCID 23157654, compound

HRID 507949Notes

Reaction equation

HRID 507949 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:23](OC)=[O:24])[CH:12]=[C:13]([C:15]2[C:20]([CH3:21])=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:22])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>O1CCCC1>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:23][OH:24])[CH:12]=[C:13]([C:15]2[C:16]([CH3:22])=[CH:17][CH:18]=[CH:19][C:20]=2[CH3:21])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 62649Sodium sulfate decahydrateHCID 21226445Aluminium lithium hydrideHCID 23157405HCID 23157405, compound

Product 1

HCID 23157654HCID 23157654, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of methyl 5-(benzyloxy)-2′,6′-dimethylbiphenyl-3-carboxylate (1.04 g, 3.00 mmol) in tetrahydrofuran (10 mL) was added lithium aluminum hydride (0.114 g, 3.00 mmol) by small portions, and the mixture was stirred under a nitrogen atmosphere at room temperature for 2 hr. Sodium sulfate decahydrate (0.967 g, 3.00 mmol) was added to the reaction mixture, and the mixture was stirred at room temperature for 1 hr. The precipitated insoluble material was filtered off through celite, and the filtrate was concentrated under reduced pressure to give the title compound (0.934 g, yield 98%) as a colorless oil.

Workup

  1. stirringthe mixture was stirred at room temperature for 1 hr
  2. filtrationThe precipitated insoluble material was filtered off through celite
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d11ffa31ccc04869aa758baeac91529a
Source dataset
uspto-grants-2010_08
Patent number
US07786165B2

Reaction notes

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