Methanesulfonic Acid → HCID 86624378, compound

HRID 508057Notes

Reaction equation

HRID 508057 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[C:11]([CH3:13])[C:10]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([CH2:20][NH:21][C:22]3[N:27]=[CH:26][C:25]([CH2:28][CH2:29][C:30]([OH:32])=[O:31])=[CH:24][CH:23]=3)[CH:15]=2)=[C:9]([CH3:33])[CH:8]=1)[CH3:2].[CH3:34][S:35]([OH:38])(=[O:37])=[O:36]>C(OCC)C.C(OCC)(=O)C>[CH3:34][S:35]([OH:38])(=[O:37])=[O:36].[CH2:1]([O:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]([CH3:33])[C:10]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([CH2:20][NH:21][C:22]3[N:27]=[CH:26][C:25]([CH2:28][CH2:29][C:30]([OH:32])=[O:31])=[CH:24][CH:23]=3)[CH:15]=2)=[C:11]([CH3:13])[CH:12]=1)[CH3:2]

Participants

5

Reactant 2

HCID 6395Methanesulfonic AcidHCID 23157445HCID 23157445, compound

Product 1

HCID 86624378HCID 86624378, compoundYield 83.4%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 3-[6-({[4′-(2-ethoxyethoxy)-2′,6′-dimethylbiphenyl-3-yl]methyl}amino)pyridin-3-yl]propanoic acid (0.729 g, 1.63 mmol) in diethyl ether (5 mL) and ethyl acetate (5 mL) was added methanesulfonic acid (0.157 g, 1.63 mmol), and the resulting crystals were washed with diethyl ether to give the title compound (0.740 g, yield 83%) as colorless crystals.

Workup

  1. washthe resulting crystals were washed with diethyl ether

Sources & evidence

ORD record
ord-bdfbaac1539b4025a3bc77a45e348583
Source dataset
uspto-grants-2010_08
Patent number
US07786165B2

Reaction notes

Loading…