HRID508077

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6395

Methanesulfonic acid

CH4O3S

结构：Cc1cc(OCCN2CCOCC2)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1

HCID23157261

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)O.CS(=O)(=O)O.Cc1cc(OCCN2CCOCC2)cc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1

HCID86624383

未命名化合物

收率 73%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

3-[4-({[2′,6′-Dimethyl-4′-(2-morpholin-4-ylethoxy)biphenyl-3-yl]methyl}amino)-2-fluorophenyl]propanoic acid (0.58 g, 1.14 mmol) was dissolved in ethyl acetate (5 mL), and methanesulfonic acid (0.08 mL) was added. The precipitated crystals were collected by filtration, washed, and dried to give the title compound as colorless crystals. yield 73%.

WORKUP

后处理

filtrationThe precipitated crystals were collected by filtration
washwashed
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-508d906953e448d5a5b0c975cc719739
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07786165B2
来源说明: uspto-grants-2010_08

反应 SMILES

[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:5]=[C:4]([CH3:17])[C:3]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][NH:25][C:26]2[CH:31]=[CH:30][C:29]([CH2:32][CH2:33][C:34]([OH:36])=[O:35])=[C:28]([F:37])[CH:27]=2)[CH:19]=1.[CH3:38][S:39]([OH:42])(=[O:41])=[O:40]>C(OCC)(=O)C>[CH3:38][S:39]([OH:42])(=[O:41])=[O:40].[CH3:38][S:39]([OH:42])(=[O:41])=[O:40].[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][N:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)[CH:5]=[C:4]([CH3:17])[C:3]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][NH:25][C:26]2[CH:31]=[CH:30][C:29]([CH2:32][CH2:33][C:34]([OH:36])=[O:35])=[C:28]([F:37])[CH:27]=2)[CH:19]=1