Methanesulfonic Acid → HCID 86624383, compound

HRID 508077Notes

Reaction equation

HRID 508077 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:5]=[C:4]([CH3:17])[C:3]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][NH:25][C:26]2[CH:31]=[CH:30][C:29]([CH2:32][CH2:33][C:34]([OH:36])=[O:35])=[C:28]([F:37])[CH:27]=2)[CH:19]=1.[CH3:38][S:39]([OH:42])(=[O:41])=[O:40]>C(OCC)(=O)C>[CH3:38][S:39]([OH:42])(=[O:41])=[O:40].[CH3:38][S:39]([OH:42])(=[O:41])=[O:40].[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][N:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)[CH:5]=[C:4]([CH3:17])[C:3]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][NH:25][C:26]2[CH:31]=[CH:30][C:29]([CH2:32][CH2:33][C:34]([OH:36])=[O:35])=[C:28]([F:37])[CH:27]=2)[CH:19]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 23157261HCID 23157261, compound

Product 1

HCID 86624383HCID 86624383, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

3-[4-({[2′,6′-Dimethyl-4′-(2-morpholin-4-ylethoxy)biphenyl-3-yl]methyl}amino)-2-fluorophenyl]propanoic acid (0.58 g, 1.14 mmol) was dissolved in ethyl acetate (5 mL), and methanesulfonic acid (0.08 mL) was added. The precipitated crystals were collected by filtration, washed, and dried to give the title compound as colorless crystals. yield 73%.

Workup

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed
  3. customdried

Sources & evidence

ORD record
ord-508d906953e448d5a5b0c975cc719739
Source dataset
uspto-grants-2010_08
Patent number
US07786165B2

Reaction notes

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