反应详情

1-(4-Chloro-phenyl)-piperazine (392 mg; 2.0 mmol) and sodium ethoxide (150 mg; 2.21 mmol) are dissolved in ethanol (2 mL) and irradiated for 5 minutes in a mono-mode microwave oven at 60° C. 2-Methyl-acrylic acid methyl ester (400 μL; 4.0 mmol) is then added and the resulting mixture is irradiated for 50 minutes in a mono-mode microwave oven at 100° C. The reaction is concentrated under reduced pressure, diluted in ethylacetate (10 mL) and extracted with water (2×5 mL). The organic phase is dried over magnesium sulphate, filtered and concentrated under reduced pressure to afford the desired product (586 mg; 1.98 mmol).

1. customirradiated for 5 minutes in a mono-mode microwave oven at 60° C
2. customthe resulting mixture is irradiated for 50 minutes in a mono-mode microwave oven at 100° C
3. concentrationThe reaction is concentrated under reduced pressure
4. additiondiluted in ethylacetate (10 mL)
5. extractionextracted with water (2×5 mL)
6. dry with materialThe organic phase is dried over magnesium sulphate
7. filtrationfiltered
8. concentrationconcentrated under reduced pressure