反应详情

20 ml of trifluoroacetic acid and 0.41 ml of trifluoromethanesulfonic acid were added, whilst ice-cooling, to a solution of 949 mg of 3-(4-methoxybenzylthio)pyrrolidin-2-one in 4 ml of anisole, and then the mixture was stirred at room temperature for 30 minutes. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure to leave a residue, which was purified by column chromatography through silica gel, eluted with a 10:1 by volume mixture of ethyl acetate and methanol, to give 728 mg of the title compound as an oil.

1. concentrationAt the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure
2. customto leave a residue, which
3. customwas purified by column chromatography through silica gel
4. washeluted with a 10:1 by volume mixture of ethyl acetate and methanol