反应详情

To a suspension of sodium hydride (60%, 55 mg, 1.4 mmol) in DMF (5 mL) was added indole (135 mg, 1.2 mmol). After stirring at room temperature for 10 min, ethyl 2-(((methylsulfonyl)oxy)methyl)cyclopropanecarboxylate (307 mg, 1.4 mmol) was added. After stirring at room temperature for 6 h, the mixture was poured into water, and the aqueous layer was extracted with EtOAc twice. The combined organic layer was dried over sodium sulfate and concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with hexane/ethyl acetate (10:1-5:1) to give 153 mg (54%) of the title compound as a pale brown oil;

1. stirringAfter stirring at room temperature for 6 h
2. extractionthe aqueous layer was extracted with EtOAc twice
3. dry with materialThe combined organic layer was dried over sodium sulfate
4. concentrationconcentrated in vacuo
5. customThe residue was purified by column chromatography on silica gel eluting with hexane/ethyl acetate (10:1-5:1)