Hydrochloric Acid → HCID 59828242, compound

HRID 512466Notes

Reaction equation

HRID 512466 reaction equation
[F:1][C:2]([F:21])([C:17]([F:20])([F:19])[F:18])[C:3]([F:16])([F:15])[C:4]1[NH:9][C:8](=[O:10])[C:7]([C:11](OC)=[O:12])=[CH:6][CH:5]=1.Cl>C(N)CC>[F:21][C:2]([F:1])([C:17]([F:20])([F:19])[F:18])[C:3]([F:15])([F:16])[C:4]1[NH:9][C:8](=[O:10])[C:7]([C:11]([NH:9][CH2:8][CH2:7][CH3:6])=[O:12])=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86624089HCID 86624089, compound

Product 1

HCID 59828242HCID 59828242, compound

Reagents, catalysts & solvents 1

HCID 7852PropylamineSolvent

Procedure

250 mg (0.78 mmol) of methyl 6-(heptafluoropropyl)-2-oxo-1,2-dihydropyridine-3-carboxylate in 5 ml of propylamine were heated under reflux for 5 h. The mixture was then adjusted to pH 2 by addition of 1N hydrochloric acid and extracted with dichloromethane. Drying and concentration gave 240 mg (88% of theory) of a beige powder.

Workup

  1. temperatureunder reflux for 5 h
  2. extractionextracted with dichloromethane
  3. customDrying
  4. concentrationconcentration
  5. customgave 240 mg (88% of theory) of a beige powder

Sources & evidence

ORD record
ord-8ef2800a049241578fd4e829a0990d92
Source dataset
uspto-grants-2015_08
Patent number
US09102623B2

Reaction notes

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