Hydrochloric Acid → HCID 117600182, compound

HRID 513223Notes

Reaction equation

HRID 513223 reaction equation
C([O:3][C:4](=[O:23])[C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][C:6]=1[C:12](=[O:22])[C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[C:15]([F:21])[CH:14]=1)C.[Li+].[OH-].O.Cl>O1CCCC1>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:4]([OH:23])=[O:3])=[C:6]([C:12](=[O:22])[C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[C:15]([F:21])[CH:14]=2)[CH:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 117599527HCID 117599527, compound

Product 1

HCID 117600182HCID 117600182, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 4-Bromo-2-(3-fluoro-5-methoxy-benzoyl)-benzoic acid ethyl ester (165 mg; 0.43 mmol) in 900 μl tetrahydrofuran is added a 1 M solution of LiOH in water (866 μl; 0.87 mmol). It is stirred at ambient temperature for 2 hours. The reaction mixture is acidified with 1 N HCl and washed with methylene dichloride several times. The organic layers are pooled, dried over MgSO4 and evaporated to dryness.

Workup

  1. washwashed with methylene dichloride several times
  2. dry with materialdried over MgSO4
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-aedf6bdb2bd349d8a68504e4bc8970eb
Source dataset
uspto-grants-2015_08
Patent number
US09102684B2

Reaction notes

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