Methanol → HCID 68183141, compound

HRID 513703Notes

Reaction equation

HRID 513703 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:7]([CH:10]2[C:23]3[CH:22]=[CH:21][C:20]4[C:15](=[N:16][CH:17]=[CH:18][CH:19]=4)[C:14]=3[NH:13][S:12](=[O:25])(=[O:24])[N:11]2[CH3:26])=[CH:6][C:3]=1[CH:4]=O.C(O[BH-](O[C:37](=O)[CH3:38])OC(=O)C)(=O)C.[Na+].[CH3:41][OH:42]>ClCCCl>[F:1][C:2]1[CH:9]=[CH:8][C:7]([CH:10]2[C:23]3[CH:22]=[CH:21][C:20]4[C:15](=[N:16][CH:17]=[CH:18][CH:19]=4)[C:14]=3[NH:13][S:12](=[O:25])(=[O:24])[N:11]2[CH3:26])=[CH:6][C:3]=1[CH2:4][NH:13][CH2:14][CH2:15][N:16]1[CH2:37][CH2:38][O:42][CH2:41][CH2:17]1

Participants

5

Reactant 3

HCID 887MethanolHCID 5049666Sodium triacetoxyborohydrideHCID 88861907HCID 88861907, compound

Product 1

HCID 68183141HCID 68183141, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

In a similar fashion, using route 37 general procedure 90, 2-fluoro-5-(2-methyl-3,3-dioxo-1,2,3,4-tetrahydro-3λ*6*-thia-2,4,5-triaza-phenanthren-1-yl)-benzaldehyde 422 (15.9 μl, 0.13 mmol) and sodium triacetoxyborohydride (40 mg, 0.19 mmol) in DCE (2 ml) gave the title compound (22 mg, 34%) after trituration from MeOH.

Sources & evidence

ORD record
ord-dbb1b926be134beda370a98b07e317f4
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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