Methanol → HCID 68190302, compound

HRID 513778Notes

Reaction equation

HRID 513778 reaction equation
C[O:2][C:3]([C:5]1[CH:22]=[C:21]2[C:8]([S:9](=[O:25])(=[O:24])[NH:10][C:11]3[C:20]2=[CH:19][C:18]([Cl:23])=[C:17]2[C:12]=3[N:13]=[CH:14][CH:15]=[CH:16]2)=[CH:7][CH:6]=1)=[O:4].[Li+].[OH-].CO.O>C1COCC1>[Cl:23][C:18]1[CH:19]=[C:20]2[C:11](=[C:12]3[C:17]=1[CH:16]=[CH:15][CH:14]=[N:13]3)[NH:10][S:9](=[O:25])(=[O:24])[C:8]1[C:21]2=[CH:22][C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 887MethanolHCID 962WaterHCID 3939Lithium HydroxideHCID 68190303HCID 68190303, compound

Product 1

HCID 68190302HCID 68190302, compoundYield 93.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a similar fashion using route 53 general procedure 121, 12-chloro-6,6-dioxo-5,6-dihydro-6λ*6*-thia-4,5-diaza-chrysene-9-carboxylic acid methyl ester 523 (0.85 g, 2.2 mmol), LiOH (190 mg, 4.5 mmol), MeOH:H2O:THF (10 ml: 3 ml: 2 ml) gave the title compound (0.74 g, 89%) after washing with MeOH.

Sources & evidence

ORD record
ord-af64f57b4eed4653a74ea143c61c6193
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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