反应详情

温度

0 °C

A solution of 1-nitro-3-[(propan-2-ylsulfanyl)methyl]benzene (4.0 g) in DCM (160 mL) was treated at 0° C. with portions of m-chloroperbenzoic acid (9.3 g, 77%). The mixture was stirred at 0° C. for further 30 minutes and then 18 hours at room temperature. The reaction mixture was diluted with DCM before sodium hydrogen sulfite and sodium bicarbonate solution was added and extracted with DCM (2×). The combined organic phases were washed and concentrated. The residue was purified by chromatography (hexane/ethyl acetate 12%-100%) to give the title compound (4.5 g).

1. custom18 hours
2. customat room temperature
3. additionwas added
4. extractionextracted with DCM (2×)
5. washThe combined organic phases were washed
6. concentrationconcentrated
7. customThe residue was purified by chromatography (hexane/ethyl acetate 12%-100%)