反应详情

温度

120 °C

A mixture of 4-iodophenol (25.0 g), 2-fluorobenzaldehyde (14.14 g), potassium carbonate (31.5 g) and dimethylformamide (500 ml) was heated at 120° C. under nitrogen with stirring for 15 hours. The mixture was cooled to ambient temperature and filtered. Water (500 ml) was added to the filtrate and the mixture was extracted with ethyl acetate to give a solid which was triturated with hot hexane (500 ml). The supernatant liquid was decanted from a residual gum and cooled. The solid which precipitated was collected by filtration to give 2-(4-iodophenoxy) benzaldehyde, m.p. 84.5-86° C.

1. temperatureThe mixture was cooled to ambient temperature
2. filtrationfiltered
3. additionWater (500 ml) was added to the filtrate
4. extractionthe mixture was extracted with ethyl acetate
5. customto give a solid which
6. customwas triturated with hot hexane (500 ml)
7. customThe supernatant liquid was decanted from a residual gum
8. temperaturecooled
9. customThe solid which precipitated
10. filtrationwas collected by filtration