反应详情

To a solution of 7-methoxy-4-nitro-1H-indole (S) (1 eq) in DMF cooled in an ice bath was added NaH (60% dispersion in oil, 1.2 eq). The reaction was stirred for 1 hr at room temperature then recooled in an ice bath. 2-Iodopropane (1.1 eq) was added then the reaction was stirred for 2 hrs at room temperature. Water and ethyl acetate were added. The ethyl acetate layer was separated and washed repeatedly (3×) with water. The ethyl acetate layer was concentrated then evaporated to dryness. Further purification by column chromatography produced the pure desired product.

1. customthen recooled in an ice bath
2. stirringthe reaction was stirred for 2 hrs at room temperature
3. customThe ethyl acetate layer was separated
4. washwashed repeatedly (3×) with water
5. concentrationThe ethyl acetate layer was concentrated
6. customthen evaporated to dryness
7. customFurther purification by column chromatography