反应详情

Benzyl bromide (5.7 g, 33.09 mmol) was added to a suspension of 3-(4-hydroxyphenyl)propanoic acid (5.0 g, 30.08 mmol) and anhydrous potassium carbonate (8.31 g, 60.17 mmol) in anhydrous DMF (60 ml), and the mixture was stirred for 15 hr. The reaction mixture was diluted with water and was extracted with ethyl acetate, and the organic layer was washed with saturated brine and was dried over anhydrous sodium sulfate. The filtrate was concentrated under reduced pressure, and the residue was chromatographed on silica gel column (hexane:ethyl acetate=8:2) to give the title compound as an oil (6.8 g, yield 88%).

1. extractionwas extracted with ethyl acetate
2. washthe organic layer was washed with saturated brine
3. dry with materialwas dried over anhydrous sodium sulfate
4. concentrationThe filtrate was concentrated under reduced pressure
5. customthe residue was chromatographed on silica gel column (hexane:ethyl acetate=8:2)