Lithium hydroxide, monohydrate → HCID 66654364, compound

HRID 517748Notes

Reaction equation

HRID 517748 reaction equation
C([O:4][CH2:5][C:6]1[N:10]([C:11]2[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[C:14]([C:21]#[N:22])=[CH:13][C:12]=2[CH3:23])[N:9]=[N:8][N:7]=1)(=O)C.O.[OH-].[Li+]>O.O1CCCC1>[OH:4][CH2:5][C:6]1[N:10]([C:11]2[C:12]([CH3:23])=[CH:13][C:14]([C:21]#[N:22])=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:16]=2)[N:9]=[N:8][N:7]=1

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 66655062HCID 66655062, compound2×

Product 1

HCID 66654364HCID 66654364, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of {1-[4-cyano-2-methyl-5-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl acetate (Intermediate 62, 433 mg, 1.33 mmol) in water (2 mL) and tetrahydrofuran (4 mL), cooled in an ice bath, was added lithium hydroxide monohydrate (56 mg, 1.33 mmol). The reaction was stirred at room temperature for 1 hour and 30 min.

Sources & evidence

ORD record
ord-15eced4b3c6847c4ba489abe7b783762
Source dataset
uspto-grants-2015_08
Patent number
US09115132B2

Reaction notes

Loading…