Iodoethane → HCID 86691897, compound

HRID 517781Notes

Reaction equation

HRID 517781 reaction equation
[CH3:1][C@H:2]1[N:7]([CH2:8][C:9]2[N:13]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=3)[N:12]=[N:11][N:10]=2)[CH2:6][CH2:5][NH:4][C:3]1=[O:24].I[CH2:26][CH3:27].[H-].[Na+]>CN(C)C=O>[CH2:26]([N:4]1[CH2:5][CH2:6][N:7]([CH2:8][C:9]2[N:13]([C:14]3[CH:15]=[CH:16][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:18][CH:19]=3)[N:12]=[N:11][N:10]=2)[C@H:2]([CH3:1])[C:3]1=[O:24])[CH3:27]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 24758Sodium hydrideHCID 86691869HCID 86691869, compound2×

Product 1

HCID 86691897HCID 86691897, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of (3R)-3-methyl-4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2-piperazinone (100 mg, 0.294 mmol, intermediate 18), in N,N-Dimethylformamide (DMF) (1 mL) was added iodoethane (0.026 mL, 0.323 mmol) and sodium hydride (23.5 mg, 0.588 mmol). The resulting reaction mixture was stirred at room temperature for 24 hours.

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-660da2f24b244f26b93149326b861867
Source dataset
uspto-grants-2015_08
Patent number
US09115132B2

Reaction notes

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