Hydrochloric Acid → HCID 71714788, compound

HRID 520977Notes

Reaction equation

HRID 520977 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[S:10]([NH:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=1[S:21][CH2:22][CH2:23][C:24]([O:26]C)=[O:25])(=[O:12])=[O:11].O[Li].O.Cl>C1COCC1.O>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[S:10]([NH:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=1[S:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])(=[O:11])=[O:12]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 71714789HCID 71714789, compound

Product 1

HCID 71714788HCID 71714788, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of methyl 3-({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenyl}sulfanyl)propanoate (125 mg, 0.29 mmol) in THF (3 ml) was added a solution of LiOH.H2O (25 mg, 0.59 mmol) in H2O (1 ml). The reaction was stirred at room temperature for 1 hour, acidified with 1M HCl, and was extracted with EtOAc.

Workup

  1. extractionwas extracted with EtOAc

Sources & evidence

ORD record
ord-efb22f226687409fb982c93ec12975a4
Source dataset
uspto-grants-2016_05
Patent number
US09328067B2

Reaction notes

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