反应详情

8-(5-iodo-2,3-dihydrobenzofuran-6-ylthio)-9H-purin-6-amine (S6-4) To a solution of S6-3 (40 mg, 0.14 mmol) in 6 mL of acetonitrile was added TFA (40 μL) and NIS (63 mg, 0.28 mmol). The resulting mixture was stirred at rt for 2 h. The reaction mixture was concentrated under reduced pressure and the residue was purified by flash chromatography (CH2Cl2:MeOH, 100:0 to 90:10) to afford S6-4 (48 mg, 53%) as a yellow gum. 1H NMR (500 MHz, CDCl3) δ 8.26 (s, 1H), 7.79 (s, 1H), 7.12 (s, 1H), 4.65 (t, J=8.8 Hz, 2H), 3.28 (t, J=8.7 Hz, 2H); MS (ESI) m/z 412.0 (M+H)+.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue was purified by flash chromatography (CH2Cl2:MeOH, 100:0 to 90:10)
3. customto afford S6-4 (48 mg, 53%) as a yellow gum