反应详情

To a solution 5 g (28.1 mmol) of 4-Hydroxycinnamic acid methyl ester, 4.9 g (35.1 mmol) of 4 bromopropanol, 9.2 g (35.1 mmol) of triphenylphosphine in 100 mL of THF are added 7.1 g (35.1 mmol) of diisopropylazodicarboxylate under inert atmosphere. The solution is heated up to reflux and allowed to stir overnight. After 20 hours, the reaction mixture is partitioned between EtOAc and water. The organic phase is washed repeatedly with water, dried over sodium sulphate, filtered and concentrated by rotary evaporation to give 7.5 g of (methyl (2E)-3-[4-(3-bromopropoxy)phenyl]prop-2-enoate.

1. temperatureThe solution is heated up
2. temperatureto reflux
3. waitAfter 20 hours
4. customthe reaction mixture is partitioned between EtOAc and water
5. washThe organic phase is washed repeatedly with water
6. dry with materialdried over sodium sulphate
7. filtrationfiltered
8. concentrationconcentrated by rotary evaporation