Lithium Hydroxide → HCID 178524246, compound

HRID 523381Notes

Reaction equation

HRID 523381 reaction equation
C[O:2][C:3]([C:5]1[C:13]2[NH:12][C:11]([C:14]3[C:15](=[O:30])[NH:16][CH:17]=[CH:18][C:19]=3[NH:20][CH2:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[CH:24]=3)=[N:10][C:9]=2[CH:8]=[CH:7][CH:6]=1)=[O:4].[Li+].[OH-].C1COCC1.O[C@@H](C1C=CC=CC=1)CNC1C=CNC(=O)C=1C1NC2C(C(O)=O)=CC=CC=2N=1>O>[Cl:29][C:25]1[CH:24]=[C:23]([CH2:22][CH2:21][NH:20][C:19]2[CH:18]=[CH:17][NH:16][C:15](=[O:30])[C:14]=2[C:11]2[NH:12][C:13]3[C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]=[CH:8][C:9]=3[N:10]=2)[CH:28]=[CH:27][CH:26]=1

Participants

6

Reactant 4

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 178497575HCID 178497575, compoundHCID 178524247HCID 178524247, compound

Product 1

HCID 178524246HCID 178524246, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-{4-[2-(3-Chloro-phenyl)-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-3H-benzoimidazole-4-carboxylic acid was synthesized from 2-{4-[2-(3-chloro-phenyl)-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-3H-benzoimidazole-4-carboxylic acid methyl ester, LiOH, THF, and water using a similar procedure as 2-[4-((S)-2-hydroxy-2-phenyl-ethylamino)-2-oxo-1,2-dihydro-pyridin-3-yl]-3H-benzoimidazole-4-carboxylic acid yielding 2-{4-[2-(3-chloro-phenyl)-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-3H-benzoimidazole-4-carboxylic acid.

Sources & evidence

ORD record
ord-1ce4f9d2d25746158f0cdc2cbff21a5d
Source dataset
uspto-grants-2016_05
Patent number
US09334480B2

Reaction notes

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