反应详情

Benzylamine (336 mg, 3.1 mmol) and potassium carbonate (865 mg, 6.2 mmol) were added to a solution of 7-(4-fluoro-3-nitrophenyl)-2-(morpholin-4-yl)quinoxalin (1.1 g, 3.1 mmol) in DMF (100 mL). The mixture was stirred 24 h at room temperature and then diluted with EtOAc. The organic phase was washed with water and saturated aqueous sodium chloride solution, then dried over sodium sulphate. After filtration and subsequent removal of solvent, the residue was purified by chromatography (silica gel, Hexane/EtOAc: 20%->100% EtOAc) giving rise to 1.29 g (93%) of the desired product.

1. washThe organic phase was washed with water and saturated aqueous sodium chloride solution
2. dry with materialdried over sodium sulphate
3. filtrationAfter filtration and subsequent removal of solvent
4. customthe residue was purified by chromatography (silica gel, Hexane/EtOAc: 20%->100% EtOAc)