反应详情

温度

100 °C

In an alternative method to Step 3, above, Tris(dibenzylideneacetone)dipalladium (1.189 g, 1.298 mmol) and xantphos (1.502 g, 2.596 mmol) were added to a degassed (3×vacuum/N2 cycles) mixture of [1-(3-bromo-5-fluoro-4-pyridyl)-4-piperidyl]-(4-methylpiperazin-1-yl)methanone 19 (10 g, 25.96 mmol) and Cs2CO3 (16.92 g, 51.92 mmol) in dioxane (150 mL) under N2. The mixture was stirred at 100° C. overnight. The reaction was cooled to ambient temperature and the precipitate was filtered off and washed with EtOAc (50 mL). The filtrate was partitioned between EtOAc and water. The combined organic layers were washed with water, brine, dried (MgSO4) and concentrated in vacuo to leave tert-butyl N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)-1-piperidyl]-3-pyridyl]carbamate as a red solid that was used in next step without further purification. MS (ES+) 422.2.

1. customa degassed
2. temperatureThe reaction was cooled to ambient temperature
3. filtrationthe precipitate was filtered off
4. washwashed with EtOAc (50 mL)
5. customThe filtrate was partitioned between EtOAc and water
6. washThe combined organic layers were washed with water, brine
7. dry with materialdried (MgSO4)
8. concentrationconcentrated in vacuo