Diisopropylcarbodiimide → Chromocarb

HRID 526285Notes

Reaction equation

HRID 526285 reaction equation
[C:1]([O:8]CC)(=[O:7])[CH2:2][CH2:3][C:4]([O-:6])=O.CC(C)N=C=N[CH:16]([CH3:18])[CH3:17]>CN(C=O)C>[CH:17]1[CH:16]=[C:18]2[C:4]([CH:3]=[C:2]([C:1]([OH:8])=[O:7])[O:6][C:4]2=[CH:3][CH:2]=1)=[O:6]

Participants

4

Reactant 2

HCID 12734DiisopropylcarbodiimideHCID 17119674-Ethoxy-4-oxobutanoate

Product 1

HCID 2741Chromocarb

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

LP-1 ctrl was synthesized by following Scheme 1 (FIG. 14). Rink SS resin was deprotected and loaded with monoethyl succinate (5 eq) and DIC (5 eq) in DMF for 2 hrs. The rest of the amino acids were added successively and the final product was purified by following the same methods described above.

Workup

  1. customthe final product was purified

Sources & evidence

ORD record
ord-c0ecd8d124ff4046b2cd3c322a7eedb2
Source dataset
uspto-grants-2016_05
Patent number
US09345789B2

Reaction notes

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