反应详情

A solution of 2.9 g of 5-(2,4-Dichloro-phenyl)-2-methyl-6-(4-trifluoromethyl-phenyl)-nicotinic acid ethyl ester and 230 mg of LiOH in 10 ml of THF and 10 ml of water was stirred at room temperature for 16 h. After 16 h, the mixture was brought to pH 2 by addition of 1 M hydrochloric acid. The reaction mixture was concentrated under reduced pressure and the aqueous layer was extracted with dichloromethane. The combined organic phases were dried over MgSO4 and the solvents were removed under reduced pressure. The residue was codistilled twice with dichloromethane and twice with toluene The isolated crude product was used in the next reaction step. Yield: 3 g.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. extractionthe aqueous layer was extracted with dichloromethane
3. dry with materialThe combined organic phases were dried over MgSO4
4. customthe solvents were removed under reduced pressure
5. customisolated crude product
6. customwas used in the next reaction step