1,1'-Carbonyldiimidazole → HCID 86692157, compound

HRID 527938Notes

Reaction equation

HRID 527938 reaction equation
[N:1]1[C:6]2[NH:7][CH:8]=[CH:9][C:5]=2[C:4]([N:10]2[CH2:14][CH2:13][C@@H:12]([N:15]([CH3:24])[C:16]3[CH:21]=[CH:20][C:19]([NH2:22])=[C:18]([NH2:23])[N:17]=3)[CH2:11]2)=[N:3][CH:2]=1.[C:25](N1C=CN=C1)(N1C=CN=C1)=[O:26]>O1CCCC1>[N:1]1[C:6]2[NH:7][CH:8]=[CH:9][C:5]=2[C:4]([N:10]2[CH2:14][CH2:13][C@@H:12]([N:15]([CH3:24])[C:16]3[N:17]=[C:18]4[NH:23][C:25](=[O:26])[NH:22][C:19]4=[CH:20][CH:21]=3)[CH2:11]2)=[N:3][CH:2]=1

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 68027261HCID 68027261, compound

Product 1

HCID 86692157HCID 86692157, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of (R)—N2-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)-N2-methylpyridine-2,5,6-triamine (35 mg, 0.11 mmol,) and 1,1′-carbonyldiimidazole (21 mg, 0.13 mmol) in tetrahydrofuran (3.0 mL) was stirred at reflux for 1 h. The volatiles were removed and the residue was purified by chromatography to give the title compound. MS (m/z): 351 (M+H)+.

Workup

  1. temperatureat reflux for 1 h
  2. customThe volatiles were removed
  3. customthe residue was purified by chromatography

Sources & evidence

ORD record
ord-6bd4e2d7e2264859b3ee432471fc190c
Source dataset
uspto-grants-2016_05
Patent number
US09346810B2

Reaction notes

Loading…