Allylamine → HCID 39871266, compound

HRID 529224Notes

Reaction equation

HRID 529224 reaction equation
[CH2:1]([NH2:4])[CH:2]=[CH2:3].[C:5](N1C=CN=C1)([N:7]1[CH:11]=[CH:10][N:9]=[CH:8]1)=[O:6]>ClCCl>[N:7]1([C:5]([NH:4][CH2:1][CH:2]=[CH2:3])=[O:6])[CH:11]=[CH:10][N:9]=[CH:8]1

Participants

4

Reactant 2

HCID 7853AllylamineHCID 682631,1'-Carbonyldiimidazole

Product 1

HCID 39871266HCID 39871266, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Allylamine (1.0 g, 17.5 mmol) was dissolved in dichloromethane (30 ml), 1,1′-carbonyldiimidazole (7.37 g, 15 mmol) was added, and the mixture was stirred overnight. The solvent was evaporated under reduced pressure, and the residue was partitioned between ethyl acetate and 1N hydrochloric acid. The organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was partitioned between ethyl acetate and 1N hydrochloric acid
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-7aabe98ebef8407eb3ccd4cb183ea754
Source dataset
uspto-grants-2016_05
Patent number
US09346821B2

Reaction notes

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