Sodium Bicarbonate → Diethyl 2-ethoxymethylimidazole-4,5-dicarboxylate

HRID 53052Notes

Reaction equation

HRID 53052 reaction equation
Cl.[CH2:2]([O:4][CH2:5][C:6]1[NH:7][C:8]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:10]=1)[CH3:3].C([O-])(O)=O.[Na+]>C(OCC)(=O)C>[CH2:2]([O:4][CH2:5][C:6]1[NH:10][C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:8]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[N:7]=1)[CH3:3]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 19036214HCID 19036214, compound

Product 1

HCID 19036215Diethyl 2-ethoxymethylimidazole-4,5-dicarboxylate

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of the diethyl 2-ethoxymethylimidazole-4,5-dicarboxylate hydrochloride thus obtained in ethyl acetate was neutralized by the addition of a saturated aqueous solution of sodium hydrocarbonate. The ethyl acetate layer was separated, dried over anhydrous magnesium sulfate and concentrated by evaporation under reduced pressure, to give the title compound as crystals, melting at 71°-74° C.

Workup

  1. customThe ethyl acetate layer was separated
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated by evaporation under reduced pressure

Sources & evidence

ORD record
ord-182e341af4d4487fa018e43965633b48
Source dataset
uspto-grants-1997_04
Patent number
US05616599

Reaction notes

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