N-(3-benzoyl-3-hydroxycyclohexyl)-3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxamide → N-(3-benzoyl-3-hydroxycyclohexyl)-3-(2-methylpyridin-4-yl)-1H-indazole-5-carboxamide

HRID 530860Notes

Reaction equation

HRID 530860 reaction equation
[C:1]([C:9]1([OH:53])[CH2:14][CH2:13][CH2:12][CH:11]([NH:15][C:16]([C:18]2[CH:19]=[C:20]3[C:24](=[CH:25][CH:26]=2)[N:23](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[N:22]=[C:21]3[C:46]2[CH:51]=[CH:50][N:49]=[C:48]([CH3:52])[CH:47]=2)=[O:17])[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)(C(F)(F)F)=O.C1(SC)C=CC=CC=1>[C:1]([C:9]1([OH:53])[CH2:14][CH2:13][CH2:12][CH:11]([NH:15][C:16]([C:18]2[CH:19]=[C:20]3[C:24](=[CH:25][CH:26]=2)[NH:23][N:22]=[C:21]3[C:46]2[CH:51]=[CH:50][N:49]=[C:48]([CH3:52])[CH:47]=2)=[O:17])[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 67985165N-(3-benzoyl-3-hydroxycyclohexyl)-3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxamide

Product 1

HCID 57410536N-(3-benzoyl-3-hydroxycyclohexyl)-3-(2-methylpyridin-4-yl)-1H-indazole-5-carboxamide

Reagents, catalysts & solvents 2

HCID 6422Trifluoroacetic acidSolventHCID 7520ThioanisoleSolvent

Procedure

A solution of N-(3-benzoyl-3-hydroxycyclohexyl)-3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxamide in a mixture of TFA (1 mL) and thioanisole (0.5 mL) was stirred at room temperature for 20 minutes, and then concentrated. The product was obtained after purification by reverse phase HPLC.

Workup

  1. concentrationconcentrated
  2. customThe product was obtained
  3. customafter purification by reverse phase HPLC

Sources & evidence

ORD record
ord-0a537cd7394e4591a5c13a0706efb9dc
Source dataset
uspto-grants-2016_05
Patent number
US09351965B2

Reaction notes

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