反应详情

温度

60 °C

Benzyl bromide (2.95 mL) was added to a DMF (200 mL) suspension of ethyl 3-ethoxy-5-hydroxy-4-iodobenzoate (7.59 g) and potassium carbonate (4.68 g), and the mixture was stirred at 60° C. for 2 hours. The reaction mixture was allowed to cool to room temperature, and then, water was added thereto, followed by extraction with ethyl acetate. The obtained organic layer was washed with saturated saline and passed through a short silica gel (NH) column, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (7.09 g).

1. temperatureto cool to room temperature
2. extractionfollowed by extraction with ethyl acetate
3. washThe obtained organic layer was washed with saturated saline
4. distillationthe solvent was distilled off under reduced pressure
5. customThe obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate)