反应详情

To a solution of methyl-4-(2-(2-fluoropropoxy)pyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate (333 mg) in THF (10 ml) was added lithium hydroxide (1M; 8 ml) and the reaction stirred at room temperature overnight. The mixture was neutralized with HCl (1M; 8 ml) and concentrated in vacuo. The crude product was purified by chromatography.

1. concentrationconcentrated in vacuo
2. customThe crude product was purified by chromatography