反应详情

温度

100 °C

Potassium carbonate (3.3 g) was added to a solution of 4-nitroguaiacol (1.0 g) and 1-(2-chloroethyl)pyrrolidine hydrochloride (1.0 g) in DMF (20.0 mL), and the mixture was heated at 100° C. overnight. The reaction mixture was then mixed with ethyl acetate and water, and the organic phase was washed twice with water, dried over sodium sulfate and concentrated. The product with the molecular weight of 266.3 (C13H18N2O4) was obtained in this way; MS (ESI): 267 (M+H+).

1. washthe organic phase was washed twice with water
2. dry with materialdried over sodium sulfate
3. concentrationconcentrated
4. customThe product with the molecular weight of 266.3 (C13H18N2O4) was obtained in this way