Oxalic acid dihydrate → HCID 86731815, compound

HRID 533683Notes

Reaction equation

HRID 533683 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]2[S:9][N:8]=[C:7]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][C@H:17]4[C@H:22]([CH2:23][N:24]5[C:34](=[O:35])[C@H:33]6[C@H:27]([C@H:28]7[CH2:32][C@@H:31]6[CH2:30][CH2:29]7)[C:25]5=[O:26])[CH2:21][CH2:20][CH2:19][CH2:18]4)[CH2:12][CH2:11]3)[C:5]=2[CH:6]=1.O.O.[C:38]([OH:43])(=[O:42])[C:39]([OH:41])=[O:40]>C(O)(C)C>[CH:1]1[CH:2]=[CH:3][C:4]2[S:9][N:8]=[C:7]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][C@H:17]4[C@H:22]([CH2:23][N:24]5[C:34](=[O:35])[C@H:33]6[C@H:27]([C@H:28]7[CH2:32][C@@H:31]6[CH2:30][CH2:29]7)[C:25]5=[O:26])[CH2:21][CH2:20][CH2:19][CH2:18]4)[CH2:12][CH2:11]3)[C:5]=2[CH:6]=1.[C:38]([O-:43])(=[O:42])[C:39]([O-:41])=[O:40]

Participants

4

Reactant 2

HCID 61373Oxalic acid dihydrateHCID 213046Lurasidone

Product 1

HCID 86731815HCID 86731815, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture consisting of isopropanol (600 mL), lurasidone base (57 g) and oxalic acid dihydrate (15 g) is refluxed for about an hour, and then cooled for two hours at ambient temperature. The solid is filtered, and 62 g of substantially pure lurasidone oxalate is obtained after drying.

Workup

  1. temperatureis refluxed for about an hour
  2. filtrationThe solid is filtered

Sources & evidence

ORD record
ord-87b6eb023cf247239b05cbd8559e0ad6
Source dataset
uspto-grants-2014_10
Patent number
US08853395B2

Reaction notes

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