反应详情

温度

120 °C

A mixture of 2-iodophenol (8.0 g, 36.4 mmol), milled potassium carbonate (5.5 g, 39.9 mmol, 1.1 eq) and 1-bromocyclopentane bromide (3.9 ml, 36.4 mmol) in 25 ml of N,N-dimethylformamide was heated at 120° C. for 1.1 hrs and cooled. The mixture was poured into water and extracted twice with ether. The ether layer was dried over magnesium sulfate, filtered, and concentrated to give an oil. The crude product was dissolved in ethyl acetate and filtered through a short pad of silica gel. The filtrate was redried over magnesium sulfate, filtered and concentrated under vacuum to give 10 g (95%) of product as an oil.

1. temperaturecooled
2. extractionextracted twice with ether
3. dry with materialThe ether layer was dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customto give an oil
7. filtrationfiltered through a short pad of silica gel
8. dry with materialThe filtrate was redried over magnesium sulfate
9. filtrationfiltered
10. concentrationconcentrated under vacuum