反应详情

A mixture of methyl 1-{[4-(2-tert-butylphenyl)piperazin-1-yl](oxo)acetyl}pyrrolidine-3-carboxylate (Example 190, 0.32 g, 0.80 mmol) and 1 M LiOH solution (5 mL, 5.0 mmol) in tetrahydrofuran (5 mL) was stirred at room temperature for 3 h. The reaction mixture was acidified with 1 M HCl solution and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the title compound (0.29 g, 92%) as a white amorphous. It was crystallized from diisopropyl ether-ethyl acetate.

1. extractionextracted with ethyl acetate
2. washThe extract was washed with brine
3. dry with materialdried over anhydrous magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure