Dimethylamine → HCID 70976030, compound

HRID 535503Notes

Reaction equation

HRID 535503 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11](=[O:18])[NH:10][N:9]=2)=[CH:4][CH:3]=1.[CH3:19][NH:20][CH3:21].C1COCC1>CN(C=O)C.CCOC(C)=O>[CH3:19][N:20]([CH3:21])[C:2]1[N:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11](=[O:18])[NH:10][N:9]=2)=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 674DimethylamineHCID 8028TetrahydrofuranHCID 86673555HCID 86673555, compound

Product 1

HCID 70976030HCID 70976030, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of the product from Example 4A (0.296 g, 1.15 mmol) and a solution of dimethylamine in THF (2 M, 2.3 mL, 4.6 mmol) in DMF (2 mL) was microwaved at 200° C. for 30 minutes, diluted with EtOAc, washed with water and brine, dried (Na2SO4), filtered, and concentrated to give 0.25 g of crude 4-(6-(dimethylamino)pyridin-3-yl)phthalazin-1(2H)-one, which was used without purification.

Workup

  1. washwashed with water and brine
  2. dry with materialdried (Na2SO4)
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-7e6ad416b175415ca9a1f6772c2e011b
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

Loading…