反应详情

3-Hydroxybenzaldehyde (2.00 g, 16.4 mmol) was dissolved in 25 mL of dry tetrahydrofuran under nitrogen with 3.5 g of potassium carbonate and 3.01 g (18.0 mmol) of ethyl bromoacetate. The reaction was heated at reflux for 6 hr, then cooled to room temperature and filtered from inorganic salts. The filtrate was evaporated, redissolved in 30 mL of methylene chloride, washed with 2×15 mL of water, and dried over sodium sulfate. Evaporation of solvent gave 2.92 of ethyl 3-formylphenoxyacetate as a yellow oil.

1. temperatureThe reaction was heated
2. temperatureat reflux for 6 hr
3. filtrationfiltered from inorganic salts
4. customThe filtrate was evaporated
5. dissolutionredissolved in 30 mL of methylene chloride
6. washwashed with 2×15 mL of water
7. dry with materialdried over sodium sulfate
8. customEvaporation of solvent