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HRID538943

反应详情

EQUATION

反应方程式

HRID 538943 的结构方程式

REACTANTS

反应物

3
结构：O=Cc1ccccc1
HCID240

Benzaldehyde

C7H6O

结构：CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
HCID5049666

Sodium triacetoxyborohydride

C6H10BNaO6

结构：Cl.NCCc1c[nH]c(=S)n1[C@H]1COc2c(F)cc(F)cc2C1
HCID10450386

未命名化合物

PRODUCTS

生成物

1
结构：Fc1cc(F)c2c(c1)C[C@@H](n1c(CCNCc3ccccc3)c[nH]c1=S)CO2
HCID25052630

Zamicastat

C21H21F2N3OS

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

A 250 L reactor was charged with 12.25 kg of (R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione hydrochloride, 114.82 kg of 2-propanol was added and the mixture was stirred at maximum speed (140 rpm). Through a dropping funnel 1.856 kg of benzaldehyde was added followed by 3.945 kg of sodium triacetoxyborohydride in five portions at Ti=20-25° C. according to the following addition order:

WORKUP

后处理

  1. additionwas added
  2. additionaccording to the following addition order