Potassium Carbonate → HCID 13882890, compound

HRID 542126Notes

Reaction equation

HRID 542126 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7](Cl)[CH:6]=[C:5]([C:15]([F:18])([F:17])[F:16])[N:4]=1.C([O-])([O-])=O.[K+].[K+].[CH3:27][C:28]1[CH:29]=[C:30]([OH:37])[CH:31]=[CH:32][C:33]=1[N+:34]([O-:36])=[O:35]>C(C(C)=O)C(C)C>[CH3:27][C:28]1[CH:29]=[C:30]([CH:31]=[CH:32][C:33]=1[N+:34]([O-:36])=[O:35])[O:37][C:7]1[CH:6]=[C:5]([C:15]([F:18])([F:17])[F:16])[N:4]=[C:3]([C:2]([F:20])([F:19])[F:1])[C:8]=1[C:9]([O:11][CH2:12][CH3:13])=[O:10]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 174123-Methyl-4-nitrophenolHCID 138828774-Chloro-2,6-bis-trifluoromethyl-nicotinic acid ethyl ester

Product 1

HCID 13882890HCID 13882890, compoundYield 95.2%

Reagents, catalysts & solvents 1

HCID 7909Methyl Isobutyl KetoneSolvent

Procedure

This product was prepared as described in Example 31: 7.0 g (0.022 mol) of product of Example 19, 3.31 g (0.024 mol) of K2CO3, 3.33 g (0.022 mol) of 3-methyl-4-nitrophenol in 75 ml of methyl isobutyl ketone were reacted affording 9.18 g of an oil. Purification by HPLC using 5% ethyl acetate/cyclohexane as eluting solvent gave 5.31 g (55.1%) of product as a yellow solid; mp 55°-57° C.

Workup

  1. customThis product was prepared

Sources & evidence

ORD record
ord-df08ab1f36c547788cdbb118c541d977
Source dataset
uspto-grants-1987_04
Patent number
US04655816

Reaction notes

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