Phenacyl bromide → HCID 13882925, compound

HRID 542136Notes

Reaction equation

HRID 542136 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7]([OH:14])[C:6]([CH3:15])=[C:5]([C:16]([F:19])([F:18])[F:17])[N:4]=1.Br[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:25].C(=O)([O-])[O-].[K+].[K+]>>[F:21][C:2]([F:20])([F:1])[C:3]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7]([O:14][CH2:23][C:24]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:25])[C:6]([CH3:15])=[C:5]([C:16]([F:19])([F:18])[F:17])[N:4]=1

Participants

4

Reactant 3

HCID 6259Phenacyl bromideHCID 11430Potassium CarbonateHCID 178469144HCID 178469144, compound

Product 1

HCID 13882925HCID 13882925, compoundYield 65.4%

Procedure

Reaction of product of Example 35 with bromoacetophenone and potassium carbonate similar to the above Example 63 gave a crude product which was recrystallized successively from methanol and cyclohexane to give 4.45 g (65.4%) of product as a solid; mp 95°-97° C.

Workup

  1. customgave a crude product which
  2. customwas recrystallized successively from methanol and cyclohexane

Sources & evidence

ORD record
ord-5de37b0cdc6b4ef9bdafc5dce0731437
Source dataset
uspto-grants-1987_04
Patent number
US04655816

Reaction notes

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