反应详情

To 50 ml of dimethylformamide containing 7.65 g (50 mmol) of 3-methyl-2-nitrophenol, 13.6 g (100 mmol) of potassium carbonate and 12.6 g (60 mmol) of 1-iodo-2,2,2-trifluoroethane were added, and the mixture was heated at 120° to 130° C. under agitation for 2 hours. Water and ether were added to the reaction mixture, and thereafter, the ether layer was concentrated to obtain 11.2 g of 2-nitro-3-(2,2,2-trifluoroethoxy)toluene as an oil.

1. temperaturethe mixture was heated at 120° to 130° C. under agitation for 2 hours
2. concentrationthe ether layer was concentrated