Dimethylformamide → HCID 13669982, compound

HRID 542651Notes

Reaction equation

HRID 542651 reaction equation
CN(C)C=O.[CH3:6][C:7]1[C:8]([N+:14]([O-:16])=[O:15])=[C:9]([OH:13])[CH:10]=[CH:11][CH:12]=1.C(=O)([O-])[O-].[K+].[K+].I[CH2:24][C:25]([F:28])([F:27])[F:26]>CCOCC.O>[N+:14]([C:8]1[C:9]([O:13][CH2:24][C:25]([F:28])([F:27])[F:26])=[CH:10][CH:11]=[CH:12][C:7]=1[CH3:6])([O-:16])=[O:15]

Participants

7

Reactant 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 210263-Methyl-2-nitrophenolHCID 677091,1,1-Trifluoro-2-iodoethane

Product 1

HCID 13669982HCID 13669982, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

To 50 ml of dimethylformamide containing 7.65 g (50 mmol) of 3-methyl-2-nitrophenol, 13.6 g (100 mmol) of potassium carbonate and 12.6 g (60 mmol) of 1-iodo-2,2,2-trifluoroethane were added, and the mixture was heated at 120° to 130° C. under agitation for 2 hours. Water and ether were added to the reaction mixture, and thereafter, the ether layer was concentrated to obtain 11.2 g of 2-nitro-3-(2,2,2-trifluoroethoxy)toluene as an oil.

Workup

  1. temperaturethe mixture was heated at 120° to 130° C. under agitation for 2 hours
  2. concentrationthe ether layer was concentrated

Sources & evidence

ORD record
ord-ab73c90b45dd4d6abea52d16a25e9f14
Source dataset
uspto-grants-1987_04
Patent number
US04659365

Reaction notes

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