Hydrochloric Acid → HCID 13423728, compound

HRID 543377Notes

Reaction equation

HRID 543377 reaction equation
[CH:1]([C:3]1[CH:8]=[C:7]([C:9]([CH3:12])([CH3:11])[CH3:10])[CH:6]=[C:5]([S:13]([CH3:16])(=[O:15])=[O:14])[C:4]=1[OH:17])=[O:2].[Mn]([O-])(=O)(=O)=[O:19].[K+].Cl.[O-]S([O-])=O.[Na+].[Na+]>[OH-].[Na+]>[C:1]([C:3]1[CH:8]=[C:7]([C:9]([CH3:12])([CH3:11])[CH3:10])[CH:6]=[C:5]([S:13]([CH3:16])(=[O:15])=[O:14])[C:4]=1[OH:17])([OH:19])=[O:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 24437Sodium SulfiteHCID 516875Potassium PermanganateHCID 134237195-tert-Butyl-2-hydroxy-3-(methanesulfonyl)benzaldehyde

Product 1

HCID 13423728HCID 13423728, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

2.56 g (0.01 mol) of 2-formyl-4-(1,1-dimethylethyl)-6-methylsulfonylphenol are introduced into a solution of 1.58 g (0.01 mol) of potassium permanganate in 50 ml of 2N sodium hydroxide solution, and the mixture is heated on a steam bath for 30 minutes. The cooled solution is then adjusted to pH 2 with 2N hydrochloric acid and decolorized with concentrated Na2SO3 solution. The mixture is extracted three times with ethyl acetate, which is evaporated in vacuo and the residue is recrystallized from acetonitrile.

Workup

  1. temperaturethe mixture is heated on a steam bath for 30 minutes
  2. extractionThe mixture is extracted three times with ethyl acetate, which
  3. customis evaporated in vacuo
  4. customthe residue is recrystallized from acetonitrile

Sources & evidence

ORD record
ord-aa59289f62e1400c8669ec0e0bec3574
Source dataset
uspto-grants-1987_04
Patent number
US04661636

Reaction notes

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