反应详情

温度

120 °C

A mixture of N-[(±)-2-chloropropionyl]isoxazolidine (16.4 g) which was prepared as in Example 1, hydroquinone (13.2 g), anhydrous potassium carbonate (29.0 g) and dimethylformamide (100 ml) was stirred at 120° C. for 2 hours. After cooling, the reaction mixture was filtered through a suction filter to remove solid matters and the filtrate was concentrated in vacuo. The residue was washed with the addition of chloroform and 1 N hydrochloric acid and then with water and dried over anhydrous sodium sulfate. Removal of the solvent by a distillation in vacuo gave N-[(±)-2-(4-hydroxyphenoxy)propionyl]isoxazolidine (21.6 g) as a pale yellow oil which was purified by silica gel column chromatography to yield a colorless oil. nD20 =1.5412.

1. temperatureAfter cooling
2. filtrationthe reaction mixture was filtered through a suction
3. filtrationfilter
4. customto remove solid matters
5. concentrationthe filtrate was concentrated in vacuo
6. washThe residue was washed with the addition of chloroform and 1 N hydrochloric acid
7. dry with materialwith water and dried over anhydrous sodium sulfate
8. customRemoval of the solvent
9. distillationby a distillation in vacuo