反应详情

温度

120 °C

Methyl p-hydroxybenzoate (11.5 g) was added to 17.0 g of 3-aminopropanol, and the mixture was stirred at 120° C. for 8 hours. Then, the reaction mixture was added to 1 N hydrochloric acid and extracted with ethyl acetate. The extract was washed with an aqueous solution of sodium chloride and dried. Evaporation of the solvent gave a crude product. The crude product was purified by silica gel column chromatography to give 9.3 g (yield 63.7%) of 4-hydroxy-N-(3-hydroxypropyl)benzamide.

1. extractionextracted with ethyl acetate
2. washThe extract was washed with an aqueous solution of sodium chloride
3. customdried
4. customEvaporation of the solvent
5. customgave a crude product
6. customThe crude product was purified by silica gel column chromatography