Hydrochloric Acid → HCID 20458320, compound

HRID 544547Notes

Reaction equation

HRID 544547 reaction equation
C([C:3]1[C:4](=[O:13])[NH:5][C:6]([CH2:11][CH3:12])=[CH:7][C:8]=1[CH2:9][CH3:10])#N.C(CC(=O)CC)(=O)CC.C(CC(N)=O)#N.C(NCC)C.Cl>C(O)C>[CH2:9]([C:8]1[CH:7]=[C:6]([CH2:11][CH3:12])[NH:5][C:4](=[O:13])[CH:3]=1)[CH3:10]

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 7898CyanoacetamideHCID 8021DiethylamineHCID 819233,5-HeptanedioneHCID 20458321HCID 20458321, compound2×

Product 1

HCID 20458320HCID 20458320, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Basu [J. Indian Chem. Soc. 7, 815 (822-3) (1930)] describes the preparation of 3-cyano-4,6-diethyl-2(1H)-pyridinone (p. 822, VI) by reacting dipropionylmethane with cyanoacetamide in ethanol in the presence of diethylamine. In this same paper Basu heated 3-cyano-4,6-diethyl-2(1H)-pyridinone with concentrated hydrochloric acid to produce 4,6-diethyl-2(1H)-pyridinone (pp. 822-3).

Sources & evidence

ORD record
ord-0c18ff1ebda34a8bb01a37f7209977ca
Source dataset
uspto-grants-1984_05
Patent number
US04451469

Reaction notes

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