反应详情

温度

70 °C

A mixture of methyl 4-hydroxybenzoate (4.03 g), 1-bromo-2-fluoroethane (5.05 g) and potassium carbonate (10.98 g) in N,N-dimethylformamide (68 ml) was stirred at 70° C. for 1 hour. The reaction mixture was cooled to room temperature, and thereto was added water. The mixture was extracted with ethyl acetate, and the organic layer was washed successively with water and brine, and then dried over magnesium sulfate. The insoluble materials were filtered off, and the filtrate was evaporated under reduced pressure to give methyl 4-(2-fluoroethyloxy)benzoate, which was used in the subsequent step without further purification.

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionThe mixture was extracted with ethyl acetate
3. washthe organic layer was washed successively with water and brine
4. dry with materialdried over magnesium sulfate
5. filtrationThe insoluble materials were filtered off
6. customthe filtrate was evaporated under reduced pressure