Potassium Carbonate → HCID 59851175, compound

HRID 544995Notes

Reaction equation

HRID 544995 reaction equation
C([O-])(O)=O.[Na+].C([O-])([O-])=O.[K+].[K+].[Cl:12][C:13]1[CH:14]=[CH:15][C:16]2[C:22](=O)[C:21](=[CH:24]N(C)C)[CH2:20][C:19](=[O:28])[N:18]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:17]=2[CH:35]=1.[NH:36]([C:40]1[CH:48]=[CH:47][C:43]([C:44]([OH:46])=[O:45])=[CH:42][CH:41]=1)[C:37]([NH2:39])=[NH:38]>CCO.CN(C=O)C>[Cl:12][C:13]1[CH:14]=[CH:15][C:16]2[C:22]3[N:38]=[C:37]([NH:36][C:40]4[CH:48]=[CH:47][C:43]([C:44]([OH:46])=[O:45])=[CH:42][CH:41]=4)[N:39]=[CH:24][C:21]=3[CH2:20][C:19](=[O:28])[N:18]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:17]=2[CH:35]=1

Participants

7

Reactant 4

HCID 11430Potassium CarbonateHCID 516892Sodium BicarbonateHCID 66934950HCID 66934950, compoundHCID 178512548HCID 178512548, compound

Product 1

HCID 59851175HCID 59851175, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6228DimethylformamideSolvent

Procedure

In a manner similar to method I (DMF and NaHCO3 were used in place of EtOH and K2CO3), 8-chloro-4-dimethylaminomethylene-1-phenyl-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-1) and 4-guanidinobenzoic acid were converted to I-10 (61%): HRMS Calcd. for C25H17ClN4O3: 457.1067, Found 457.1076.

Sources & evidence

ORD record
ord-a2256dbeabc5447096ed9aa0b37ce2de
Source dataset
uspto-grants-2011_05
Patent number
US07935694B2

Reaction notes

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