反应详情

温度

60 °C

0.72 g (3.75 mmol) of N-(4-acetyl-3-hydroxy-phenyl)acetamide and 0.81 g (4.1 mmol) of 2-bromo-4-methylacetophenone were dissolved in 5 ml DMF and 1,55 g (11.25 mmol) of potassium carbonate were added. The suspension was heated to 60° C. for 1 h and ethylacetate was added. The organic phase was washed three times with water, one time with a NaCl solution, dried over Na2SO4 and concentrated in vacuo. The residue was further purified by crystallisation (ethanol).

1. washThe organic phase was washed three times with water, one time with a NaCl solution
2. dry with materialdried over Na2SO4
3. concentrationconcentrated in vacuo
4. customThe residue was further purified by crystallisation (ethanol)