Hydrochloric Acid → 10-[2-Hydroxy-2-(4-chlorophenyl)ethyl]-2,3,4,10-tetrahydropyrimidino[1,2-a]benzimidazole hydrochloride

HRID 54707Notes

Reaction equation

HRID 54707 reaction equation
Cl.[OH:2][CH:3]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)[CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N:7]2[CH2:14][CH2:15][CH2:16][N:17]=[C:6]12>C(O)(C)C>[ClH:24].[OH:2][CH:3]([C:18]1[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=1)[CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N:7]2[CH2:14][CH2:15][CH2:16][N:17]=[C:6]12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 28997651-(4-chlorophenyl)-2-(3,4-dihydropyrimido[1,2-a]benzimidazol-10(2H)-yl)ethanol

Product 1

HCID 289976410-[2-Hydroxy-2-(4-chlorophenyl)ethyl]-2,3,4,10-tetrahydropyrimidino[1,2-a]benzimidazole hydrochloride

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Slowly add isopropanolic hydrogen chloride to an isopropanol solution of the base obtained in Step A. Wait for 30 minutes. Suction-filter, and wash with acetone.

Workup

  1. filtrationSuction-filter
  2. washwash with acetone

Sources & evidence

ORD record
ord-0abcd3d5c3e549099ebe9ca4ca331704
Source dataset
uspto-grants-1997_04
Patent number
US05623073

Reaction notes

Loading…